Leg-perthes

[galaxie11 0]

J'aimerais avoir de l'information sur cet maladie le leg -perthe,vient -elle du mâle ou de la femelle ,est-elle hériditaire a 100%,
Merci

[MJo1 0]

http://en.wikipedia.org/wiki/Legg-Calv%C3%A9-Perthes_syndrome

Ça c'est pour l'humain mais c'est probablemen la même chose chez le chien.

[Vega03 0]

J'ai demandé à ma clinique et ils n'ont pas ces données. Faudrait que je demande aux spécialistes en chirurgie. Mais selon les vets régulier, c'est très sérieux et demande absolument une chirurgie au plus vite.

[Sasha1111 0]

Tiré de http://www.minpin.org/health_files/Legg_baugh.htm

Legg-Calve-Perthes Disease has been thought to be caused by a single factor of multiple factors, some of which are trauma, metabolic, hormonal, infections, genetic and vascular: Predisposition for small pure bred dogs leads investigators to the conclusion that genetics plays a role in LCPD. The fact that two or more pups in a litter may be affected lends support to this theory. Hormonal influences have also been suspect. It is felt since smaller breeds mature earlier and consequently have higher levels of sex hormones (estrogens in females/androgens in males) that these higher levels may initiate the avascular necrosis, Trauma is another factor believed to play a role, It is not a single traumatic incident but rather an overactive puppy which continually jumps up and stands upright on it's rear legs for prolonged periods, This repeated minor trauma may lead to joint effusion (excess joint fluid) which in turn causes a decrease (by increasing pressure on vessels) in blood supply to the femoral head. Whatever the cause or causes blamed, an underlying factor common to all is evident - lack of adequate blood flow to the femoral head, The result of this decreased blood flow leads to a progressive osteoarthritis of the hip joint and possible shortening and thickening of the femoral neck, Ischemia (lack of blood to area) is the initial problem followed by death of the femoral head, then revascularization and demineralization of the bone of the femoral head. After demineralization the bone is soft and fragments and collapses on itself, Without bone support, the cartilage of the femoral head cracks and also dies, Given enough time the femoral head will heal and recalcify, only it is flattened and misshapen, The end result of degenerative joint disease spells pain and lameness for the dog.

How is this disease transmitted? Is it monosomal, bisomal, or multisomal? Not enough experimentation has been done to know, We can only speculate that a recessive gene is responsible. It seems to skip generations. What can be done? First, examine all of your breeding stock and eliminate the affected animals. Diagnosis may be made by an x-ray of suspicious candidates, Legg-Perthes will in most cases show healed lesions on the femoral head and neck.

Et de http://www.showdog-magazine.com/medical/legperth.htm

The term "avascular necrosis" means death of tissue due to lack of blood supply. In most dogs, only one hip is affected, and males and females are equally affected.(2) Why this loss of blood supply to the area occurs is not known. What is known however, is the genetic nature of the condition. The exact mode of inheritance of LPD has been debated among researchers. Pidduck et al.,(3)working with toy poodles, proposed a simple (autosomal) recessive mode of inheritance. Robinson,(4) working with data on West Highland white terriers, Yorkshire terriers, miniature poodles and pugs, also suggested an autosomal recessive.

In an effort to clarify the mode of inheritance, Vasseur et al.,(5) working with the Manchester terrier club, conducted a test breeding. Two affected individuals were bred, and all five resulting puppies were X-rayed monthly to check for signs of LPD. If the disease were inherited as a simple recessive in Manchester terriers, then the mating of two affected individuals should have produced 100% affected puppies. At the seven month radiographic examination, changes were noted in three of the puppies, and all three subsequently became lame. The two remaining puppies had no radiographic changes through nine months of age, and remained sound until 16 months when they were placed in homes.

This study indicates that either LPD has a multigenic (more than one gene) mode of inheritance in Manchester terriers, or that it is not completely expressed. That is, an animal may have the affected genes, but not show signs of the disease. Regardless of the exact mode of inheritance, statistical analysis of this and other studies reveals that LPD has a high degree of heritability.

[Sophie46 0]

Comme a dit Sasha, c'est une maladie génétique par transmission autosomique récessive. Donc, les deux parents doivent être porteur du gène pour qu'un chiot développe la maladie. Si un seul des parents est porteur du gène, certains chiots seront «sains» et d'autre seront «porteurs» du gène.

Appelée, aussi, nécrose aseptique de la tête fémorale, cette maladie apparaît en général sur des chiots âgés de plus de quatre mois et de moins d'un an. Elle se traduit par un défaut de vascularisation de la tête et du col du fémur. Elle est, le plus souvent, unilatérale. Le cartilage se déforme, après modification de la tête fémorale. Le chien souffre, et boite de plus en plus. Il ne prend plus appui sur le membre malade, qui se démuscle. L'opération est nécessaire et relativement lourde. Elle consiste en l'ablation de la tête et du col du fémur. Une néo-articulation se forme. le chien ne souffre plus, et retrouve une démarche presque normale. La transmission génétique de cette maladie est avérée. Il faut s'interdire de faire reproduire des chiens atteints de cette maladie à composante héréditaire. Et même, pour éviter cette maladie, les éleveurs doivent sélectionner des reproducteurs n'ayant aucune histoire familiale de la maladie de Leggs-Calvé-Perthes.

Bref, c'est une maladie très douloureuse... Je le sais parce que c'est ce que mon Toby a eu...

Je te met un lien qui explique et illustre bien la transmission autosomique récessive. http://fr.wikipedia.org/wiki/Transmission_autosomique_r%C3%A9cessive

[Sasha1111 0]

Merci Sophie. J'avais pas du tout le temps de traduire ce soir.

[galaxie11 0]

Merci ,ce fut très instructif